Fig. 2.

Effect of vehicle and 2.4 mg/kg of tonabersat on mixed a-wave (a) and b-wave (b) amplitude on the ERG 3 months post-treatment of light-damaged rats. The rod PIII (c) and PII (d) analysis shows untreated animals have significantly reduced amplitudes compared to their amplitude prior to light damage. Treated animals have maintained retinal function, matching the controls for Rod PII and only slightly lower for Rod PIII. All average data are expressed as mean ± SEM. Statistical analysis was performed using a two-way ANOVA and a Bonferroni post hoc test of the a- and b-wave values. Statistical analysis of rod PII and PIII was performed using an unpaired t test with a Welch’s correction. Significant values are indicated with asterisks: ***p < 0.001. LD = light damage