Increased numbers of interneurons in the VB in the absence of retinal input. (A and B) GFP+ GABAergic interneurons in the dorsal thalamus of P0 to P30 Gad67-GFP (A) and Gad67-GFP::Math5−/− mice (B). (Scale bars, 150 µm.) (C–E) Summary of age-related changes in GFP+ interneuron number in the VB (triangles) and dLGN (circles) of Gad67-GFP and Gad67-GFP::Math5−/− mice. Data points represent means ± SEM, Asterisks (*) in C represent significance (P < 0.001) between control and mutant [two-way ANOVA, F(1,
134) = 94.43, P < 0.0001; Holm–Sidak post hoc test, P values < 0.001].