Fig. 6.

Biological pathways involved in the functional remodeling of proteome solubility. (A) GO terms for proteins significantly changed in solubility in two or more stresses. Shown are the top tier GO terms tested with Fisher's exact test and Bonferroni post hoc testing with P < 0.05. (B) The proportion of detected SG proteins using the curated list of Markmiller et al. (22) for proteins in the indicated number of stresses. Black circle indicates background proteome. Colored circles indicate proteins that significantly changed solubility. Fisher's exact test results comparing stress to background are shown (*P < 0.05; **P < 0.01; ****P < 0.0001) (Dataset S3—test 9). Mean and 95% CIs shown from proportions analysis (Dataset S3) (C) Barcode graph of SG proteins from Markmiller et al. (22) and solubility.