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. 2019 Dec 11;7(2):e651. doi: 10.1212/NXI.0000000000000651

Figure 2. Biochemical characterization of pTau in anti-IgLON5 brains.

Figure 2

Immunoblot of insoluble tau aggregates extracted from (1) Alzheimer disease prefrontal cortex tissue, (2) hippocampus of the patient with anti-IgLON5 described in the main text, and (3) brainstem of a previously described patient with anti-IgLON5 with the characteristic brainstem tauopathy. Note that the pattern of bands obtained with anti-phospho-tau antibodies clearly differentiates the 2 IgLON5 cases. In the patient with the brainstem pathology, the 74-KDa band is more intense and appears a differential band around 56 KDa that immunoreacts with the 4R antibody. Both IgLON5 cases have 3R and 4R pTau isoforms. pTau = phosphorylated tau.