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. 2020 Feb 8;19:13. doi: 10.1186/s12933-020-0994-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Immunoblotting for cardiac proteins involved in calcium handling and contractility in Fischer F344 rats following sham surgery or left anterior descending artery ligation (MI) and treated with vehicle or empagliflozin (20 mg/kg/day) by oral gavage for 6 weeks beginning 1 week after surgery. a Serine 16 phosphorylated phospholamban (PLN). b Threonine 17 phosphorylated PLN. c Serine 473 phosphorylated Akt. d Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). e Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). f SERCA2a. n = 6/group. Values are mean ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001 by two-way ANOVA followed by Fisher’s least significant difference post hoc test