Fig. 4.

Lisa can accurately identify key transcriptional regulators and co-regulators using Cistrome DB cistromes. Lisa analyses of up- and downregulated gene sets from a GR overexpression, b BCL6 knockdown, c MYC knockdown, and d SOX2 knockout experiments. The scatter plots show negative log₁₀ Lisa p values of 1316 unique transcriptional regulators for up- and downregulated gene sets. Colors indicate log₂ fold changes of the TF gene expression between treatment and control conditions in the gene expression experiments. Dots outlined with a circle denote transcriptional regulators that physically interact with the TF perturbed in the experiment, which is marked with a cross