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. Author manuscript; available in PMC: 2021 Jan 17.
Published in final edited form as: Circ Res. 2019 Nov 6;126(2):200–209. doi: 10.1161/CIRCRESAHA.119.315686

Figure 2. Prevalence and penetrance of TTNLOF variants with respect to atrial fibrillation and heart failure.

Figure 2.

Figure 2A exhibits the proportion of carriers with high confidence loss-of-function variants in cardiac TTN (TTNLOF) and 95% confidence intervals among unrelated atrial fibrillation (AF), heart failure (HF), and nonischemic cardiomyopathy (CMP) cases. Figure 2B shows the penetrance of TTNLOF variants for AF, HF, and CMP. Of the three diseases, TTNLOF variants are most frequent among individuals with non-ischemic cardiomyopathy. All values are calculated from an unrelated subset of the exome sequencing cohort (N = 41,212). AF cases with HF prior to AF are excluded.