Table 1.
Selected articles
| Author/year | Area | Level of evidence | Number of hips/patients | Mean Age | Gender (F/M) | Stage | Etiology | Mean Follow-up (m) | Treatment/procedure | Findings/Conclusion | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cheng/2014 | Australia | Basic science | 12/12 | 6-8 weeks | Male piglets | N/A | Surgical induced | 8 weeks | -Group1:Saline ,Group2: rhBMP-2y, 3: rhBMP-2+local Bisphosphonate -Intra-osseous injection |
local delivery of rhBMP-2 and bisphosphonates in the sugar-based carrier significantly prevent collapse | |
| Lieberman/ 2004 |
USA | III | 17/15 | 47y | 60%/40% | Ficat IIA-III | Steroid (main) | 53 m | CD + fibular allograft+ 50 mg BMP-2 | 82.4% had a successful clinical results (HHS >80) | |
| Sun/2014 | Asia | III | 79/46 | 31y | 57 %/43% | ARCO (IIb-IIIa) and CJFH (C-L3)* | Steroid (main) |
73m | Group1:debridement+IBG**+rhBMP-2*** Group2: debridement+ IBG |
82% vs. 72% good and excellent results in rhBMP-2 group | |
| Zhou/2014 | Asia | Basic science | 74/74 | 6-8 weeks | Male rats | N/A | Surgical induced | 8 weeks | -Group1:sham group, 2:BSA # 3: BMP-2-injected 4:a COMP-Ang1##+ BMP-2-injected - Injection to the epiphysis |
combined intraosseous injection of COMP-Ang1 and BMP-2 effectively repaired ischemic damage by inducing angiogenesis and osteogenesis |
|
| Vandermeer/ 2011 |
USA | Basic science | 22/22 | 6-8 weeks | Male piglets | N/A | Surgical induced | 8 weeks | Group1:normal, 2:treated with saline solution,3: treated with ibandronate, 4: treated with ibandronate + BMP-2 |
better preservation of the femoral head shape, trabecular bone volume, thickness, and number and for osteoblast surface in the ibandronate +BMP-2 group | |
| Ma/2015 | Asia | Basic science | 36/36 | 6 months | Rabbit (GenderN/A) | N/A | liquid nitrogen freezing induced | 8 weeks | Group1:CD, 2:CD + BMSCs### ,3:CD+ VEGF ¥ /BMP-2 transfect BMSCs |
VEGF/BMP-2 gene transfection strengthened osteogenic effects of BMSCs, and accelerated the bone repair that observed arthroscopically | |
| Aruwajoye/ 2016 |
USA | Basic science | 25/25 | 5–8 weeks | Male piglets | N/A | Surgical induced | 8 weeks | Group1:normal control, 2:untreated, 3:Ibandronate, 4:BMP-2,5: BMP-2 +Ibandronate | BMP-2 and BMP-2 + ibandronate normalize the material properties of bone than ibandronate alone | |
*China-Japan Friendship Hospital classification system
** Impacted bone graft
***recombinant human BMP-2
# Bovine serum albumin
## Cartilage oligomeric matrix protein angiopoietin-1
### Bone marrow mesenchymal stem cells
¥ Vascular endothelial cell growth factor