Table 1.
Effects of oral recombinant Lactococcus lactis in high cholesterol diet of rabbits on body weight and serum parameters.
| Measurement | Sham | VO | LZ8 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| W0 | W3 | W5 | W0 | W3 | W5 | W0 | W3 | W5 | |
| Body weight (Kg) | 2.62 ± 0.32 | 2.75 ± 0.25 | 2.79 ± 0.26 | 2.38 ± 0.30 | 2.51 ± 0.23 | 2.61 ± 0.38 | 2.58 ± 0.25 | 2.72 ± 0.29 | 2.83 ± 0.23 |
| Cholesterol (mg/dL) | 38 ± 8.6 | 1264 ± 214∗∗ | 1487 ± 552∗∗∗ | 41.5 ± 22.9 | 831.3 ± 511.3∗ | 1342 ± 258∗∗∗ | 39.3 ± 8.1 | 1390 ± 602∗∗ | 1980 ± 394.7∗∗∗ |
| HDL-chol (mg/dL) | 19 ± 5.8 | 30 ± 7.9 | 31.5 ± 11.2 | 14.2 ± 4.9 | 39.2 ± 11.9 | 26.5 ± 11.7 | 20.5 ± 4.7 | 29.25 ± 8.7 | 21.8 ± 5.6 |
| LDL-chol (mg/dL) | 8.5 ± 3.6 | 527.9 ± 80.9∗∗ | 540.8 ± 237.5∗∗ | 9.85 ± 7.9 | 291.3 ± 198.8∗ | 520.5 ± 96.1∗∗∗ | 7.05 ± 2.2 | 558.1 ± 262.3∗∗ | 773.2 ± 121.9∗∗∗ |
| Triglyceride (mg/dL) | 56.5 ± 14.5 | 89.5 ± 68.3 | 111.5 ± 52.8 | 44 ± 14.6 | 79.8 ± 58.5 | 71.3 ± 28.7 | 45.8 ± 5.3 | 79 ± 44.0 | 110.8 ± 64.9 |
| AST (U/L) | 24.2 ± 9.1 | 348.5 ± 156.9∗∗ | 107.5 ± 57.1 | 18 ± 5.6 | 179.5 ± 40.9∗∗∗ | 52 ± 25.5 | 36 ± 18.9 | 83.3 ± 73.8 | 73.2 ± 29.2 |
| ALT (U/L) | 44.3 ± 22.6 | 304 ± 94.2∗∗∗ | 134 ± 59.7 | 33.5 ± 5.8 | 183.7 ± 58.7∗∗∗ | 78.5 ± 25.8 | 54 ± 22.8 | 84.3 ± 47.9 | 98.3 ± 57.5 |
HDL, high-density lipoproteins; LDL, low-density lipoproteins; AST, aspartate aminotransferase; ALT, alanine aminotransferase.Values are means ± SD of 4 rabbits from each group. The statistics show comparisons between W0 and W3 or W0 and W5 from each group by the Bonferroni multiple range test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.