Table 2.

After pediatric arterial ischemic stroke (N=114), unadjusted odds ratios and 95% confidence intervals for clinical factors associated with acute seizures (≤7 days post-stroke) and epilepsy at one-year (N=109 with one year follow-up).

	Acute Seizures (N=58)		Epilepsy (N=11)
	OR	P-value	OR	P-value
Demographics
Male	0.8 (0.4–1.7)	0.5	1.4 (0.4–5.2)	0.6
North American	0.6 (0.3–1.4)	0.3	1.1 (0.3–4.5)	0.9
Hispanic parent	0.9 (0.3–2.2)	0.7	1.0 (0.2–5.0)	1
Neonatal stroke	22 (4.9–99)	<0.001*	1.2 (0.3–4.7)	0.8
Years of age at stroke, median (IQR)†	0.8 (0.7–0.9)	<0.001*	0.7 (0.5–1.0)	0.03*
Stroke Risk Factors
Cardiac disease	1.6 (0.7–3.7)	0.3	0.6 (0.1–3.2)	0.6
Arteriopathy	0.2 (0.1–0.6)	0.001*	0.9 (0.2–3.6)	0.9
Acute illness	1.1 (0.5–2.3)	0.9	2.8 (0.8–10)	0.1
Underlying chronic disease	0.7 (0.3–1.6)	0.3	0.7 (0.1–3.5)	0.7
Head trauma	0.4 (0.1–2.0)	0.2	n/a	1
Infarct Description
MCA territory	2.8 (1.2–6.3)	0.01*	1.4 (0.3–5.4)	0.7
ACA territory	0.7 (0.2–2.1)	0.5	1.6 (0.3–8.3)	0.6
PCA territory	0.7 (0.3–1.8)	0.4	0.9 (0.2–4.6)	0.9
Cortical location	1.3 (0.5–3.2)	0.6	2.3 (0.6–9.0)	0.2
Multifocal	1.2 (0.6–2.6)	0.6	2.1 (0.6–7.4)	0.3
Hemorrhage	1.3 (0.3–6.1)	0.7	1.9 (0.2–18)	0.6
History of seizure before stroke	4.1 (0.4–38)	0.2	n/a	0.4
Acute seizure (any)			11 (1.4–92)	0.02*
No acute seizure			Ref	0.005‡
Single acute seizure			6 (0.3–101)	0.2
2–10 acute seizures			7.7 (0.8–72)	0.07
> 10 acute seizures			31 (2.9–305)	0.004*

^*P ≤ 0.05.

^†Non-neonates.

^‡P-value, test for trend across ordinal catgories. Abbreviations: OR = Odds ratio, CI= 95% confidence interval, IQR = interquartile range, MCA = middle cerebral artery, ACA = anterior cerebral artery, PCA = posterior cerebral artery