Table 1:
Characteristics of study population
| Monotherapy, N = 94 | Treatment interruption, N = 174 | Without monotherapy or treatment interruption | |
|---|---|---|---|
| Number of patients | 84 | 147 | 3,233 |
| Median age, y (IQR) | 15.0 (12.9, 16.5) | 14.5 (12.5, 16.4) | 14.9 (12.4, 17.6)a |
| Median duration, d (IQR) | 198 (117, 365) | 182 (65, 343) | |
| Sex | |||
| Female | 59 (62.8) | 101 (58.1) | 1,644 (50.9) |
| Country | |||
| Cambodia | 1 (1.1) | 1 (.6) | 412 (12.8) |
| India | 1 (1.1) | 15 (8.6) | 208 (6.4) |
| Indonesia | 0 | 0 | 122 (3.8) |
| Malaysia | 14 (14.9) | 11 (6.3) | 241 (7.5) |
| Thailand | 77 (81.9) | 144 (82.8) | 1,463 (45.3) |
| Vietnam | 1 (1.1) | 3 (1.7) | 787 (24.3) |
| Age at ART initiation, years | |||
| <3 | 23 (24.5) | 10 (5.8) | 531 (16.4) |
| 3–4 | 12 (12.8) | 14 (8.1) | 519 (16.1) |
| 5–9 | 35 (37.2) | 73 (42.0) | 1,390 (43.0) |
| ≥10 | 24 (25.5) | 77 (44.3) | 665 (20.6) |
| Naïve | 0 | 0 | 128 (4.0) |
| Preceding CD4 count, cells/μLb | |||
| Median (IQR) | 403 (193, 697) | 349 (132, 673) | 675 (385, 947) |
| ≥500 | 38 (40.4) | 64 (36.8) | 1,978 (61.2) |
| 350–499 | 12 (12.8) | 19 (10.9) | 321 (9.9) |
| 200–349 | 14 (14.9) | 32 (18.4) | 217 (6.7) |
| <200 | 23 (24.5) | 52 (29.9) | 463 (14.3) |
| Unknown/missing | 7 (7.5) | 7 (4.0) | 254 (7.9) |
| Preceding HIV viral load, copies/mLb | |||
| <400 | 11 (11.7) | 57 (32.8) | 1,258 (38.9) |
| 400—999 | 4 (4.3) | 3 (1.7) | 59 (1.8) |
| 1,000—9,999 | 21 (22.3) | 23 (13.2) | 94 (2.9) |
| ≥10,000 | 49 (52.1) | 54 (31.0) | 315 (9.7) |
| Unknown/missing | 9 (9.6) | 37 (21.3) | 1,507 (46.6) |
| Preceding WHO clinical stageb | |||
| I/II | 93 (98.9) | 160 (92.0) | 2,870 (88.8) |
| III/IV | 1 (1.1) | 14 (8.0) | 363 (11.2) |
| Preceding ART adverse eventb | |||
| No | 89 (94.7) | 153 (87.9) | 3,190 (98.7) |
| Yes | 5 (5.3) | 21 (12.1) | 43 (1.3) |
| Combination ART regimens | |||
| 1 | 31 (33.0) | 101 (58.1) | 2,053 (63.5) |
| ≥2 | 56 (59.6) | 72 (41.4) | 1,046 (32.4) |
| Naïve | 7 (7.5) | 1 (.6) | 134 (4.1) |
Values n (%) unless otherwise specified.
ART = antiretroviral therapy; IQR = interquartile range; WHO = World Health Organization.
a
Age at last clinic visit.
b
Baseline data for population without monotherapy or treatment interruption.