Table A.

Participant characteristics by age quartile at baseline.

Variable	Age 70-75, n=187		Age 76-80, n=205		Age 81-83, n=160		Age 84-101, n=197		Total N=749
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Age	73.48	1.37	78.11	1.39	81.86	0.85	87.35	3.27	80.18	5.52
Female n, %	125	66.84	133	64.88	122	76.25	151	76.65	531	70.89
Education in years	11.66	4.72	11.58	4.7	9.89	5.18	9.49	4.54	10.69	4.86
Race/ethnicity n, %
White	59	31.55	85	41.46	35	21.88	54	27.41	233	31.11
African-American	61	32.62	49	23.9	50	31.25	59	29.95	219	29.24
Hispanic	67	35.83	71	34.63	75	46.88	84	42.64	297	39.65
BOMC cognition (0-28)	1.97	3.14	2.81	4.12	3.53	3.83	3.76	4.47	3	3.99
B-SIT (0-12)	8.77	2.13	8.34	2.5	7.79	2.38	7.59	2.56	8.13	2.44
CES-D	1.20	1.38	1.30	1.46	1.37	1.56	1.26	1.37	1.28	1.44
Transition to dementia n, %	16	8.56	24	11.71	25	15.63	44	22.34	109	14.55
*Cognitive decline n, %	25	13.59	33	16.34	39	26	50	26.60	147	20.3
**ApoE e4 positive n, %	50	27.32	47	24.1	33	20.75	43	22.16	173	23.67
***Smoking, n%
Current	19	10.22	11	5.39	9	5.66	4	2.04	43	5.77
Past	52	27.96	63	30.88	50	31.45	57	29.08	222	29.80
Never	115	61.83	130	63.73	100	62.89	135	68.88	480	64.43

B-SIT: Brief Smell Identification Test, range 0-12, higher scores indicate better odor identification test performance, 0-10 impaired, 11-12 intact.

BOMC: Blessed Orientation Memory Concentration Test, range 0-28, higher scores indicate worse cognitive performance, ≥ 6 impaired, 0-5 intact

CES-D: Center for Epidemiological Studies Depression Scale. Scoring range 0-60, with higher scores indicating greater depressive symptomatology.

^*25 participants had missing data

^**18 participants had missing data

^***4 participants had missing data