Table:

Multivariable-Adjusted Logistic Regression Models for the Risk of Incident Cardiovascular Disease Risk Factors with Increasing Liver Fat

	Number of participants	Model	OR (95% Confidence Interval)	p value
Hypertension‡	654	MV†	1.22 (0.96, 1.55)	0.11
		MV + BMI + ΔBMI†	1.06 (0.81, 1.38)	0.69
Diabetes‡	788	MV	1.66 (1.25, 2.21)	<0.001
		MV + BMI + ΔBMI	1.68 (1.23, 2.30)	0.001
Impaired Fasting Glucose‡	585	MV	1.51 (1.22, 1.87)	<0.001
		MV + BMI + ΔBMI	1.28 (1.00, 1.63)	0.05
Hypercholesterolemia‡	661	MV	1.13 (0.93, 1.37)	0.23
		MV + BMI + ΔBMI	1.05 (0.84, 1.31)	0.68
Low HDL‡	565	MV	1.38 (1.01, 1.88)	0.04
		MV + BMI + ΔBMI	1.25 (0.88, 1.76)	0.21
Hypertriglyceridemia‡	574	MV	1.14 (0.92, 1.43)	0.23
		MV + BMI + ΔBMI	1.04 (0.81, 1.34)	0.74
Metabolic Syndrome‡	608	MV	1.76 (1.36, 2.26)	<0.001
		MV + BMI + ΔBMI	1.55 (1.19, 2.03)	0.001

MV, multivariable; BMI, body mass index; HDL, high density lipoprotein.

^†MV model adjusts for baseline age, sex, baseline smoking status (former, current, never), baseline drinks per week, baseline liver phantom ratio, and baseline continuous outcome variables (baseline SBP and DBP for hypertension, baseline glucose for diabetes and impaired fasting glucose, baseline total cholesterol for hypercholesterolemia, baseline HDL for low HDL, baseline log triglycerides for hypertriglyceridemia and baseline waist circumference, log triglycerides, HDL, glucose, SBP and DBP for the metabolic syndrome). The MV+ BMI + ΔBMI was additionally adjusted for baseline BMI and change in BMI.

^‡Hypertension was defined as systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg, or treatment with antihypertensive medication. Diabetes mellitus was defined as fasting glucose ≥ 126 mg/dL or use of hypoglycemic medications including insulin. Impaired fasting glucose was defined as fasting glucose 100 to 125 mg/dL in the absence of hypoglycemic medications. Hypercholesterolemia was defined as a total cholesterol ≥ 240 mg/dL or use of lipid-lowering medication. Low HDL cholesterol was defined as < 50mg/dL for women or < 40 mg/dL for men. Hypertriglyceridemia was defined as triglycerides ≥ 150 mg/dL or lipid treatment. Metabolic syndrome was defined as present if a participant had three or more of the following characteristics: abdominal obesity, defined as waist circumference greater > 35 inches for women or 40 inches for men, triglycerides ≥ 150 mg/dL, HDL cholesterol < 50 mg/dL for women and < 40 mg/dL for men, a systolic blood pressure ≥ 130 mm Hg or a diastolic blood pressure ≥ 85 mm Hg, or a fasting glucose ≥ 110 mg/dL.