Table 3:

Sicca symptoms, signs, and treatment by EMS marker status

	EMS positive	EMS negative	P value
Self-reported dry mouth, % (n)	59.4% (19)	58.3% (7)	0.25
DE symptoms, mean (SD)
Years with DE symptoms	11.5 (12.5)	10.0 (11.8)	0.74
DEQ5 (0–22)	16.3 (3.2)	16.1 (2.3)	0.81
OSDI (0–100)	59.7 (21.2)	57.6 (18.3)	0.80
Pain intensity (0–10) 1 week recall	5.8 (3.0)	5.3 (2.8)	0.70
Burning (0–10)	5.0 (3.2)	5.4 (4.4)	0.83
Sensitivity to wind (0–10)	5.2 (3.1)	5.3 (3.4)	0.98
Sensitivity to light (0–10)	6.4 (2.9)	5.5 (3.5)	0.53
DE signs, mean (SD)
Inflammadry* (range 0–3)	1.1 (0.1)	1.5 (0.7)	0.21
TBUT* (seconds)	4.2 (2.6)	5.7 (4.6)	0.36
Conjunctivochalasis* (range 0–3)	0.4 (0.4)	0.3 (0.6)	0.61
Corneal staining* (range 0–15)	5.3 (4.3)	4.2 (3.6)	0.43
Persistent pain after anesthesia (range 0–10)	2.0 (2.3)	1.9 (2.8)	0.91
Schirmer score at 5 min* (mm)	5.0 (4.0)	6.5 (5.6)	0.45
Topical medications†, % (n)
Artificial tears	100.0% (32)	83.3% (10)	0.07
Cyclosporine	100.0% (32)	75.0% (9)	0.02
Lifitegrast	40.6% (13)	8.3% (1)	0.07
Ketotifen	18.8% (6)	8.3% (1)	0.65

^*All dry eye signs represent score in the more severely affected eye.

^†Current or prior

EMS=Early Markers of Sjögren’s; SD=standard deviation; DE=dry eye; DEQ5=Dry Eye Questionnaire 5; OSDI=Ocular Surface Disease Index; TBUT=tear break up time