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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2019 Oct 23;19(2):564–574. doi: 10.1158/1535-7163.MCT-19-0366

Table 1.

Pharmacokinetics of Cer in mice bearing OVCAR-3 tumors administrated NBD Cer-RUB nanomicelles. tmax, time to reach Cmax; Cmax, maximum concentration of Cer; t1/2, elimination half-life; AUC, area under the concentration-time course.

Tissues tmax (h) Cmax (ng/ml or ng/mg) AUC (ng*h/ml) t1/2 (h)
Serum 3 0.60 3.714 6.82
Tumor 3 0.36 2.83 9.02
Lung 3 0.92 4.77
Colon 3 0.42 1.63