Table 1:

Review of original paper checklist criteria and translation to PICU Warning Tool

	Criterion	Definition or adaptation* in PICU Warning Tool, or reason for exclusion
Unchanged	High Mean Airway Pressure	Mean airway pressure sustained greater than 20 cm H20 for at least 2 hours
	Extracorporeal Membrane Oxygenation (ECMO)	Any patient receiving veno-venous or veno-arterial ECMO (up to 24 hours post decannulation)
Adapted	Pulmonary Hypertension	Most recent nitric oxide gas value > 5 parts per million AND   • Active pulmonary hypertension on problem list OR   • Received medication indicating pulmonary hypertension in prior 24 hours
	Use of two vasoactive medications OR high dose single drug	Medication Administration Record within the last 6 hours of:   • Any dose of phenylephrine, dobutamine, or vasopressin   • Any two of the following: dopamine, epinephrine, or norepinephrine   • Epinephrine or norepinephrine with dose>0.1 mcg/kg/min   • Dopamine with dose >5 mcg/kg/min
	Traumatic Brain Injury	• Sustained elevated intracranial pressure > 20 for most recent 2 hours • 3% saline or mannitol bolus in prior 6 hours for high ICP
	PICU Initiated Renal Replacement Therapy	First 5 hours on CRRT and first 5 hours off of CRRT
	Potassium >7.0	Two consecutive potassium laboratory values >7 mmol/L (resulted with the last 24 hours)
	pH<7.1	Most recent pH laboratory value (resulted within the past 24 hours)<7.1
	Lactate>10	Most recent lactate laboratory result >10 mmol/L
Added	Severe Cardiac Dysfunction	• Mixed venous saturation<60% without 2 consecutive values >70% within the last 24 hours OR • Milrinone infusion within the previous 6 hours
Excluded	Stage 1 Hypoplastic Left Heart Repair in Past 24 hours	HLH patients not cared for in the study PICUs
	Recent life-threatening event requiring code team activation or cardiac arrest	No standardized EHR documentation of events
	Intubation/Extubation of known difficult or critical airway	Difficult or critical airway is reliably captured at both institutions, intubation not documented until post procedure.
	Provider Intuition	Concern on the part of an attending physician that a patient is high-risk regardless of criteria met cannot be captured in an automated fashion.
	Anticipated tracheal intubation of known diagnosis of myocarditis	Tracheal intubations are only documented post procedure.

^*Adaptations noted in italics