Fig. 5.

Lack of miR-181a-5p enhances antiviral CD8⁺ T cell responses in vivo. miR-181a^−/− and miR-181a^+/+ littermates were infected intranasally with 10⁴ PFU of murid herpesvirus 4 (MuHV-4). (a) Percentages of activated (CD44⁺) CD8⁺ T cells expressing IFN-γ as assessed by intracellular staining. (b) Viral loads (PFU) quantified by ex vivo reactivation assays in which latently infected splenocytes (harvested at days 7, 10 and 14 postinfection) were co-cultured with permissive BHK-21 cells. Each dot represents one mouse. Horizontal lines indicate the mean. * P ≤ 0.05