Fig. 6.

Theoretical framework of cognitive reserve functioning in MS. WM was shown to be a mechanism linking cognitive performance (in particular in a task of long-term memory) and individual factors (Sandry and Sumowski 2014) (a). In this and previous studies (Bonzano et al. 2009) we demonstrated that in PwMS brain damage leads to increased widespread neural activity, in spite of a reduced cognitive performance (b). However, an effective cognitive rehabilitation treatment can increase WM capacity, reduce compensatory activity and restore, at least in part, cognitive performance (c)