Fig. 1.

Schematic representation of the multiple applications of endophytic Penicillium species isolated from medicinal plants. Briefly, our investigation showed that endophytes isolated from plant tissues were identified using morphological and molecular tools. For their applications, these species were cultured in a liquid or solid medium to produce metabolites purified and identified using various chromatographic and spectroscopic tools. Their biological activities were evaluated using multiples set of assays for drug discovery and agricultural purposes. Also, the ability of the whole organism to sequester heavy metals and toxic compounds for the detoxification of nature, to produce important enzymes or to biotransform compounds were intensively investigated