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. Author manuscript; available in PMC: 2020 Feb 9.
Published in final edited form as: J Med Chem. 2019 Apr 9;62(8):4193–4203. doi: 10.1021/acs.jmedchem.9b00378

Table 6.

2D Matrix Indicates Low ClogP is Favorable for Achieving Antinociceptive Activity

graphic file with name nihms-1067893-t0011.jpg

(A) Ligand matrix indicates trends in lipophilicity, as measured by ClogP. Compounds with highest ClogP (least desirable) are displayed in darker shades of blue whereas more polar analogues are shown in white. (B) Antinociceptive activity, measured by the WWTW assay, is displayed as the percent maximal possible effect (%MPE). Compounds with the least antinocicetive activity in this assay (least desirable) are depicted in darker shades of blue whereas those with the highest activity are shown in white.