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. 2020 Feb 6;8:e8509. doi: 10.7717/peerj.8509

Table 1. GO enrichment and KEGG pathway analysis of differently expressed RBPs.

GO term P value FDR
Down-regulated RBPs
mRNA processing 3.68E−09 <0.0001
mRNA metabolic process 2.43E−10 2.2102E−06
RNA processing 1.86E−08 0.0001
regulation of translation 2.60E−08 0.0001
regulation of cellular amide metabolic process 9.26E−08 0.0002
RNA cap binding complex 1.14E−06 0.0007
ribonucleoprotein complex 1.19E−06 0.0007
RNA binding <0.0001 <0.0001
mRNA binding 5.88E−11 5.52E−08
single-stranded RNA binding 8.12E−10 5.08E−07
mRNA 3′-UTR binding 1.65E−08 7.6E−06
mRNA 3′-UTR AU-rich region binding 2.02E−08 7.6E−06
TGF-beta signaling pathway 0.0004 0.0376
Up-regulated RBPs
RNA processing <0.0001 <0.0001
peptide metabolic process <0.0001 <0.0001
amide biosynthetic process <0.0001 <0.0001
peptide biosynthetic process <0.0001 <0.0001
translation <0.0001 <0.0001
ncRNA metabolic process <0.0001 <0.0001
ribonucleoprotein complex <0.0001 <0.0001
ribonucleoprotein granule <0.0001 <0.0001
cytoplasmic ribonucleoprotein granule 2.22E−16 8.70E−14
nucleolus 8.46E−13 2.45E−10
P granule 1.46E−12 2.45E−10
RNA binding <0.0001 <0.0001
catalytic activity, acting on RNA <0.0001 <0.0001
mRNA binding <0.0001 <0.0001
poly-pyrimidine tract binding 5.45E−08 <0.0001
translation regulator activity 1.39E−07 <0.0001
mRNA surveillance pathway <0.0001 <0.0001
RNA degradation <0.0001 <0.0001
RNA transport <0.0001 <0.0001
Ribosome 0.0001 0.0001
Aminoacyl-tRNA biosynthesis 0.0079 0.0079