Figure 4.

Comparative analysis of anti‐RTA and anti‐RTB MAbs in protecting KCs, J774E, and LSECs from ricin toxin. Area under the curve (AUC) analysis of ricin‐toxin neutralizing activities of a collection of MAbs targeting (A) RTA and (B) RTB. Cytotoxicity assays were performed across a range of MAb concentrations (starting at 20 µg/ml), as described in the section Materials and Methods. AUC values and corresponding 95% confidence intervals were determined for each antibody from the results of ricin neutralization assays, with 4–13 biologic replicates per concentration