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. 2020 Feb 4;14:497–508. doi: 10.2147/DDDT.S237957

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© 2020 Al-Sanea et al.

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Scheme 1 — Synthesis of target HDAC inhibitors 7a-c and 8a,b; Reagents and conditions: (i) KMnO₄ solution, heating 50°C 12 h, (ii) CDI, THF, r.t. 2 h, then TFA, r.t.10 h, (iii) THF, CDI, 60°C 6 h.