Table 1.

HDAC1 and HDAC2 Inhibitory Activities of the Newly Synthesized Ligustrazine-Based Derivatives 7a-7c and 8a, b

Compound	IC50 (nM)
	HDAC1	HDAC2
7a	114.3 ± 0.44	53.7 ± 0.05
7b	2434.7 ±1.25	132.3 ± 0.12
7c	263.5 ± 1.27	205.4 ± 0.43
8a	468.1 ± 0.08	168.8 ± 0.13
8b	1800.1 ± 0.45	112.9 ± 0.09
Dacinostat	129.4 ± 0.07	136.3 ± 0.11

Note: Data were expressed as mean ± standard error (S.E.) of three independent experiments.