Table 2.

History of hypersensitivity and exposure to known triggers among U.S. reports of Erythema Multiforme (EM), Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), or SJS/TEN to VAERS, 1999–2017.

	EM (%), (n = 984)	SJS (%), (n = 89)	SJS/TEN (%), (n = 6)	TEN (%), (n = 7)	Total, N = 1086
Infection, no. (%)
Yes	4 (<1)	2 (2)	0 (0)	0 (0)	6 (1)
No	980 (>99)	87 (98)	6 (100)	7 (100)	1080 (99)
Medication,a no. (%)
Anticonvulsant	1 (<1)	5 (6)	0 (0)	2 (29)	8 (1)
Antibiotics
Sulfa drugs	4 (<1)	3 (3)	0 (0)	1 (14)	8 (1)
Penicillin	52 (5)	3 (3)	1 (17)	0 (0)	56 (5)
Macrolides	6 (1)	3 (3)	0 (0)	0 (0)	4 (<1)
NSAIDsb	11 (1)	6 (7)	0 (0)	0 (0)	8 (1)
Acetaminophen	5 (1)	5 (6)	0 (0)	0 (0)	10 (1)
Existing/history of hypersensitivity,a no., (%)
EM-SJS-TEN	6 (1)	5 (6)	0 (0)	0 (0)	11 (1)
Atopic dermatitis	25 (3)	2 (2)	1 (17)	1 (14)	29 (3)
Respiratory allergiesc	47 (5)	4 (4)	0 (0)	1 (14)	52 (5)
Drug allergy
Anticonvulsant	0 (0)	1 (1)	0 (0)	0 (0)	1 (<1)
Antibiotics
Sulfa drugs	8 (1)	2 (2)	0 (0)	0 (0)	10 (1)
Penicillin	27 (3)	6 (7)	1 (17)	0 (0)	34 (3)
Macrolide	7 (1)	0 (0)	1 (17)	0 (0)	8 (1)
NSAIDs	4 (<1)	3 (3)	0 (0)	0 (0)	7 (1)
Acetaminophen	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)

^aNot mutually exclusive.

^bNSAID = non-steroidal anti-inflammatory drug.

^cIncludes asthma/reactive airway disease, allergic sinusitis, and allergic bronchitis.