Fig. 6.

Alteration of inhibitory and excitatory synapses and the levels of NLGN2 in the brains of SIV/HIV-infected subjects. a, d Representative confocal images of the frontal cortex regions of SIV/HIV-infected subjects were stained with Gephyrin (inhibitory postsynaptic marker) and PSD95 (excitatory postsynaptic marker). b, e Quantification of Gephyrin and PSD95 puncta. c, d and g, h Expression level of NLGN2 is significantly reduced in the brains of SIV/HIV-infected subjects. Bars represent mean ± SD from 3 independent experiments. * p < 0.05; ** p < 0.01 vs. uninfected controls