Table 2.
Univariate and multivariate Cox analyses of OS in the whole cohort
| Variable | University analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| CEA level | < 0.001 | < 0.001 | ||
| Normal | Reference | Reference | ||
| Elevated | 3.414 (2.754–4.231) | 2.417 (1.928–3.030) | ||
| Basophil level | < 0.001 | < 0.001 | ||
| ≥ 0.025*109/L | Reference | Reference | ||
| < 0.025*109/L | 2.150 (1.746–2.648) | 1.748 (1.410–2.168) | ||
| T stage | < 0.001 | 0.038 | ||
| T1 | Reference | Reference | ||
| T2 | 0.882 (0.375–2.074) | 0.773 | 0.553 (0.232–1.318) | 0.181 |
| T3 | 2.201 (1.013–4.784) | 0.046 | 0.945 (0.419–2.129) | 0.891 |
| T4a | 3.638 (1.716–7.717) | 0.001 | 1.136 (0.510–2.531) | 0.755 |
| T4b | 6.344 (2.731–14.736) | < 0.001 | 1.312 (0.532–3.232) | 0.555 |
| N stage | < 0.001 | <0.001 | ||
| N0 | Reference | Reference | ||
| N1a | 1.744 (1.120–2.717) | 0.014 | 1.610 (1.008–2.574) | 0.046 |
| N1b | 2.094 (1.407–3.116) | < 0.001 | 2.124 (1.384–3.259) | 0.001 |
| N1c | 3.626 (2.584–5.089) | < 0.001 | 2.634 (1.811–3.830) | <0.001 |
| N2a | 3.995 (2.883–5.536) | < 0.001 | 2.764 (1.891–4.041) | <0.001 |
| N2b | 6.292 (4.609–8.591) | < 0.001 | 4.590 (3.150–6.687) | <0.001 |
| Gender | 0.351 | |||
| Male | Reference | |||
| Female | 1.104 (0.897–1.358) | |||
| Histology | < 0.001 | 0.447 | ||
| Adenocarcinoma | Reference | Reference | ||
| Mucinous adenocarcinoma | 1.292 (0.996–1.676) | 0.054 | 1.125 (0.833–1.519) | 0.443 |
| Signet ring cell carcinoma | 3.166 (1.881–5.330) | < 0.001 | 1.402 (0.788–2.493) | 0.250 |
| Tumor location | < 0.001 | 0.005 | ||
| Right colon | Reference | Reference | ||
| Left colon | 0.555 (0.399–0.774) | 0.001 | 0.590 (0.420–0.829) | 0.002 |
| Rectum | 0.632 (0.503–0.795) | < 0.001 | 0.742 (0.584–0.944) | 0.015 |
| Tumor grade | < 0.001 | 0.119 | ||
| Well | Reference | Reference | ||
| Moderate | 2.123 (1.126–4.004) | 0.020 | 1.874 (0.986–3.564) | 0.055 |
| Poor | 3.590 (1.890–6.819) | < 0.001 | 2.013 (1.036–3.910) | 0.039 |
| Venous invasion | < 0.001 | 0.033 | ||
| No | Reference | Reference | ||
| Yes | 2.165 (1.762–2.660) | 1.290 (1.021–1.630) | ||
| Perineural invasion | < 0.001 | 0.164 | ||
| No | Reference | Reference | ||
| Yes | 1.867 (1.509–2.310) | 1.181 (0.934–1.493) | ||
| Lymph nodes dissected in total | 0.325 | |||
| < 12 | Reference | |||
| ≥ 12 | 1.140 (0.878–1.480) | |||
| Age (years) | < 0.001 | < 0.001 | ||
| < 65 | Reference | Reference | ||
| ≥ 65 | 1.849 (1.501–2.276) | 1.658 (1.329–2.068) | ||
| Adjuvant chemotherapy | 0.111 | < 0.001 | ||
| No | Reference | Reference | ||
| Yes | 0.813 (0.631–1.049) | 0.491 (0.369–0.652) | ||