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. Author manuscript; available in PMC: 2020 Feb 10.
Published in final edited form as: Expert Opin Drug Discov. 2019 Sep 20;14(12):1255–1268. doi: 10.1080/17460441.2019.1659242

Figure 4.

Figure 4.

(a) Chemical structures of CC-885 (19), CC-220 (20), compound 10 (21)and compound 15 (VH298) (22)and F-Hyps epimers (23), (b) Crystal structure of CC-885 (purple sticks) with GSPT1 (light blue surface) and CRBN (magenta surface) [PDB 5HXB], (c) Crystal structure of CC-220 (purple sticks) with DDB1 (light blue surface) and CRBN (red surface) [PDB 5V3O], (d) Crystal structure of compound 10 (magenta sticks) with pVHL:EloB:EloC (light blue surface) [PDB 5NVX], E) Crystal structure of compound 15/VH298 (green sticks) with pVHL:EloB:EloC (light blue surface) [PDB 5LLI].The figure was prepared in Pymol (The PyMOL molecular graphics system, version 2.0 Schrödinger, LLC).