Table 3.

Effects of E. coli LF82 on transepithelial resistance [TER] and short-circuit current [Isc] in human ileum

Group/treatment	TER [Ω × cm2]		Isc [μA/cm2]
Non-IBD controls	VE	FAE	VE	FAE
Vehicle	74.1 [62.8–79.9]	79.2 [65.7–82.3]	11.9 [9.9–13.5]	13.7 [11.2–15.3]
LF82	67.1 [58.7–72.0]	73.3 [61.2–79.7]	13.7 [9.9–15.8]	15.2 [11.9–17.1]
Crohn’s disease	VE	FAE	VE	FAE
Vehicle	69.6 [59.5–73.8]	74.2 [63.5–77.9]	13.9 [11.5–15.1]	15.5 [11.2–18.5]
LF82	63.1 [52.3–71.7]	70.2 [65.7–75.9]	15.7 [13.4–17.5]	18.4 [14.0–20.2]

Segments of villus epithelium [VE] and follicle-associated epithelium [FAE] from nine non-inflammatory bowel disease [IBD] controls and eight patients with Crohn’s disease were mounted in Ussing chambers and exposed to vehicle or E. coli LF82. Comparisons were made with the Mann–Whitney U test. The values above, median [25th–75th percentiles], represent the recordings at 90 min, but there were no significant effects on TER or Isc by E. coli LF82 at any time point.