Table 2.
Modeling of Lidocaine Release from Different Formulations
| Formulation Code | Zero-Order (Qt=Q0 +kt) | First-Order LnQt=LnQ0 +kt | Higuchi-Order Qt=k +t | Korsmeyer–Peppas Qt/Q1 = Ktn (n= 0.5, 0.75, 1.25) | ||||
|---|---|---|---|---|---|---|---|---|
| R2 | K | R2 | K | R2 | K | R2 | K | |
| N1 | 0.7500 | 1.932 | 0.8520 | 0.026 | 0.9329 | 7.848 | 0.9134 | 6.174 |
| N2 | 0.7136 | 2.570 | 0.8716 | 0.041 | 0.9280 | 10.539 | 0.9154 | 8.756 |
| N3 | 0.5149 | 4.255 | 0.8377 | 0.122 | 0.9822 | 18.090 | 0.8520 | 17.726 |
| N4 | 0.2198 | 5.281 | 0.9720 | 0.227 | 0.9839 | 23.436 | 0.8111 | 28.179 |
Notes: R2 is the correlation coefficient; K is the release rate constant for respective models. Where Qt is the amount of drug released at time t, Q1 is the initial amount of drug k is release rate constants of respective equation.