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. 2020 Feb 5;12:841–854. doi: 10.2147/CMAR.S240773

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© 2020 He et al.

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Mechanism of CTC isolation and detection CellCollector. (A) Pictorial representation of the CellCollector wire and its application. (B) Representative pictures of WBCs and CTC (bar = 10 μm). EpCAM antibodies coated wire facilitates binding of EpCAM positive cells when exposed into the arm vein of cancer patients. (C) Identification of EpCAM/CKs positive CTC from patients. Cancer cells were observed for EpCAM- and/or pan-keratin-positive (green) and CD45-negative (red) events. Nuclear counterstaining (blue) was performed by Hoechst33342 (bar = 10 μm). (D) The CTC detection rate in lung cancer patients and healthy control. (E) The CTC detection in stage I and stage II. (F) The CTC detection in male and female. (G) The CTC detection in person with differential smoking history [NS, never smoker; FS, former smoker; CS, current smoker]. (H) The CTC detection rate in three types of tumor size: ≤3 cm, 3–5 cm and >5 cm.