Table 2.
Multivariate Cox regression analysis of prognostic factors in patients with dermatomyositis
| Variables | HR (95% CI) | P‐value |
|---|---|---|
| Univariate analysis | ||
| Age of onset, years | 1·044 (1·020–1·070) | < 0·001 |
| Sex | 1·459 (0·800–2·663) | 0·218 |
| ILD | 0·982 (0·529–1·820) | 0·953 |
| RP‐ILD | 3·690 (2·019–6·743) | < 0·001 |
| Muscle weakness | 2·342 (1·127–4·867) | < 0·05 |
| Myalgia | 1·785 (0·997–3·195) | 0·051 |
| Mechanic’s hands | 1·050 (0·559–1·970) | 0·880 |
| Raynaud’s phenomenon | 1·386 (0·587–3·274) | 0·457 |
| Skin ulcer | 2·764 (1·483–5·151) | < 0·05 |
| Gottron papules | 1·154 (0·641–2·077) | 0·633 |
| Calcinosis | 0·045 (0·000–25·831) | 0·339 |
| Arthritis/arthralgia | 1·248 (0·680–2·290) | 0·475 |
| Dysphagia | 2·565 (1·430–4·601) | < 0·01 |
| CAM | 2·472 (1·273–4·803) | < 0·01 |
| Anti‐MDA5 antibody | 2·634 (1·433–4·841) | < 0·01 |
| Anti‐TIF1‐γ antibody | 2·592 (1·337–5·023) | < 0·01 |
| Anti‐synthetase antibodies | 0·372 (0·147–0·942) | < 0·05 |
| CK > 200 IU/l | 2·590 (1·451–4·624) | < 0·01 |
| LDHa > 250 IU/l | 2·313 (1·269–4·213) | < 0·01 |
| CRPb > 0·8 mg/dl | 3·124 (1·681–5·803) | < 0·001 |
| ESRc > 20 mm/h | 3·895 (1·995–7·605) | < 0·001 |
| Ferritind > 306·8 ng/ml | 6·124 (2·472–15·175) | < 0·001 |
| sCD163 | 1·000 (1·000–1·001) | 0·378 |
| CD3+ T cell numbere < 808 cells/μl | 2·079 (1·053–4·103) | < 0·05 |
| Neopterin > 22·1 nmol/l | 6·017 (2·896–12·501) | < 0·01 |
| Multivariate analysis | ||
| Age, years | 1·027 (1·000–1·055) | < 0·05 |
| Sex | 0·898 (0·475–1·698) | 0·742 |
| RP‐ILD | 2·451 (1·178–5·101) | < 0·05 |
| CAM | 3·327 (1·404–7·885) | < 0·01 |
| Anti‐MDA5 antibody | 2·994 (1·391–6·444) | < 0·01 |
| Anti‐TIF1‐γ antibody | 2·097 (0·846–5·197) | 0·11 |
| Neopterin > 22·1 nmol/l | 4·619 (2·092–10·195) | < 0·001 |
HR = hazard ratio; CI = confidence interval; ILD = interstitial lung disease; RP‐ILD = rapidly progressive ILD; CK = creatine kinase; LDH = lactate dehydrogenase; CRP = C‐reactive protein; ESR = erythrocyte sedimentation rate; CAM = cancer‐associated myositis; TIF1 = transcriptional intermediary factor; MDA5 = melanoma differentiation‐associated gene. aData available for 181 patients; bdata available for 171 patients; cdata available for 172 patients; ddata available for 99 patients; edata available for 164 patients.