Figure 5.

Treatment of humanized non‐obese diabetic‐severe combined immunodeficient (NOD‐SCID) gamma (NSG) mice with anti‐annexin A1 (ANX A1) antibody suppresses the appearance of various lupus immunoglobulin (Ig)G antibodies and of proteinuria. A representative of three independent experiments is shown. All samples were triplicated and average values were used for analysis. Mean ± standard deviation values were calculated for each group; P‐values were calculated using the two‐way analysis of variance (anova) test (*P < 0·05; **P < 0·01; ***P < 0·001) in comparison to control antibody‐treated mice. (a) The anti‐ANX A1 antibody administration prevented the appearance of high titres of IgG anti‐dsDNA antibodies (upper panel) and resulted in a non‐significant change of albuminuria (lower panel). (b) The same treatment of the group influenced various lupus IgG and IgM autoantibody levels measured by microarrays.