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. 2020 Feb 7;2020:7083575. doi: 10.1155/2020/7083575

Figure 4.

Figure 4

SSR suppressed the nuclear translocation and transactivation of p53 in the CKD model. (a) Representative immunoblot demonstrating decreased nuclear P53 protein content and phosphorylation (Ser15) 8 weeks after SSR treatment in 5/6 (A/I) rats. (b) Quantification of nuclear P53 protein content and phosphorylation normalized to lamin B1 protein (n = 4). (c) Normalized content of Bax, Puma, and Noxa mRNA 8 weeks after SSR treatment. The abundance of each mRNA was normalized to β-actin, and data were expressed as a fold increase over control (n = 4). Values are mean ± SEM. ∗P < 0.05, ∗∗P < 0.01.