Figure 6.

Prooxidant genes in the skeletal muscle of obese Zucker rats. Gene expression of NADPH oxidase 2 (Nox2), Nox4, and p22phox in musculus quadriceps of control obese Zucker rats and in obese Zucker rats receiving AVE0991 via osmotic minipumps for two weeks, determined by real-time PCR. Data were normalized to the gene expression of 40S ribosomal protein S29 (Rps29) whose expression was not altered by the treatment. Data presented as mean ± S.E.M. were analysed by Student's t-test, ^∗p < 0.05; ^∗∗p < 0.01.