Table 1.

Meta-analytic results for variance ratios and coefficients of variance ratio

	n			VR meta-analysis			r (M, SD)		CVR meta-analysis
	Trials	AD	Placebo	VR (95% CI)	p value	Q(df)	AD	Placebo	CVR (95% CI)	p value	Q(df)
AD all	169	32 650	18 746	1.01 (0.99 to 1.02)	0.33	121.74 (168)	0.55**	0.52**	0.82 (0.80 to 0.84)	0.00	243.53 (168)**
SSRI	89	13 146	9024	1.01 (0.99 to 1.04)	0.32	124.94 (88)**†	0.56**	0.45**	0.83 (0.80 to 0.86)	0.00	137.29 (88)**
SNRI	53	9970	7226	1.00 (0.98 to 1.03)	0.66	14.26 (52)	0.53**	0.56**	0.81 (0.78 to 0.84)	0.00	70.37 (52)**
Atypical	54	8780	6293	1.00 (0.97 to 1.02)	0.69	17.62 (53)	0.71**	0.74**	0.83 (0.79 to 0.86)	0.00	61.53(53)
Tricyclics	11	754	771	1.04 (0.95 to 1.14)	0.40	15.80 (10)	−0.34	0.64*	0.65 (0.58 to 0.72)	0.00	6.96 (10)

r (M, SD) is the Pearson correlation of mean pre–post differences in depression (M) and the respective SD. Q(df) is the heterogeneity index for the meta-analysis. *p<0.05, **<0.01

†This result was caused by an outlier (Study Dube 2010, NCT00420004), and after removing this study, the heterogeneity index was Q(df=87)=54.54, p=0.99.

AD, antidepressant; CVR, coefficient of variance ratio; VR, variance ratio.