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. Author manuscript; available in PMC: 2020 Feb 10.
Published in final edited form as: J Cell Physiol. 2017 Feb 3;232(11):2946–2956. doi: 10.1002/jcp.25824

FIGURE 1.

FIGURE 1

Ion channels in lifespan modulation. A: C. elegans TRPA-1 channel mediates the cold-promoted longevity through FOXO transcription factor DAF-16, while mouse TRPV1 shortens lifespan through transcription co-factor CRTC1. B: CNG channels TAX-2 and TAX-4 are involved in the odorant- and heat-modulated lifespan through FOXO transcription factor DAF-16 and nuclear hormone receptor DAF-12, respectively. C: Multiple voltage-gated calcium channels modulate brain aging. D: ENaC channels PPK-28 and PPK-23 suppress longevity in Drosophila. E: Potassium channel Shaker may influence aging through circadian clock