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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Int J Cancer. 2019 Dec 9;146(7):1862–1878. doi: 10.1002/ijc.32771

Figure 4.

Figure 4.

NEXN is the candidate target gene underpinning the lung cancer susceptibility locus for never-smokers on 1p31.1. The upper left panel shows the genetic associations with lung cancer in never-smokers in TRICL-ILCCO OncoArray. The bottom left panel shows the lung eQTL statistics for NEXN. The location of genes is illustrated at the bottom. The right panel shows boxplots of gene expression levels in the lung according to genotype groups for Laval, Groningen, and UBC samples. The y-axis shows the mRNA expression levels. The x-axis shows the three genotype groups for the SNP most strongly associated with lung cancer (upper right) and the SNP most strongly associated with mRNA expression of NEXN (lower right) with the number of individuals in parenthesis. The risk allele in TRICL-ILCCO OncoArray is shown in red. [Color figure can be viewed at wileyonlinelibrary.com]