Fig. 4.

Local analysis of the SHG emission directionality. (a) Measured F/B as a function of depth into normal (blue) and IPF (red) tissues; solid and open symbols correspond to measured and simulated responses, respectively. The resulting $F_{\mathrm{SHG}}/B_{\mathrm{SHG}}$ in $15\times 15\text{\hspace{0.17em}\hspace{0.17em}pixel}$ patches for (b) normal and (c) IPF tissues. Number of stacks were 34 and 75 for IPF and normal, respectively. $\text{Scalebar}=30\mu \mathrm{m}$.