Table 8.

Predictive values for soluble CD44, CD44v6, CD44v8-10 and EpCAM for predicting CCA recurrence using the optimal cut-off derived from the ROC curve in early stage of CCA patients

Variables	AUC (95% CI)	Cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	p
CD44	0.670 (0.521–0.819)	0.505	68.0	63.0	51.7	77.4	0.029
CD44v6	0.670 (0.529–0.811)	0.814	68.0	68.0	55.6	78.8	0.029
CD44v8-10	0.702 (0.563–0.841)	0.713	73.0	71.0	59.3	81.8	0.010
EpCAM	0.739 (0.598–0.880)	0.506	68.0	76.0	62.5	80.6	0.002

CD44 cluster of differentiation 44, CD44v CD44 variant, EpCAM epithelial cell adhesion molecules, AUC area under curve, 95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value