Prostate
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Positive |
In vivo tumor inhibition: This study validates the significance of NO on inhibition of castration-resistant prostate cancer (CRPC) tumors through tumor microenvironment (TME) |
Arora et al. (2018)
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Shows the ability of NO to attenuate hypoxia-induced progression of prostate cancer |
Siemens et al. (2009)
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Small molecules able to inhibit WNT and androgen receptor (AR) signaling via NO release represent a promising platform for the development of new compounds for the treatment of CRPC |
Laschak et al. (2012)
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Inhibits epithelial–mesenchymal transition. Treatment of human prostate metastatic cell lines with the NO donor, DETANONOate, inhibits epithelial–mesenchymal transition and reverses both the mesenchymal phenotype and the cell-invasive properties |
Baritaki et al. (2010)
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Inhibits cellular proliferation. GIT-27NO, an NO donor, inhibited in vivo prostate cancer cell growth of PC3 and LnCap cells |
Donia et al. (2009)
|
Lung
|
Positive |
Decrease in epithelial–mesenchymal transition. NO serves a critical role in preserving an epithelial phenotype and in attenuating epithelial–mesenchymal transition in alveolar epithelial cells |
Vyas-Read et al. (2007)
|
|
Negative |
Promotes angiogenesis. In vivo, NO has a role in maintaining tumor blood supply, and we provide early clinical evidence that inhibition of NO synthesis has tumor antivascular activity |
Ng et al. (2007)
|
Gastric
|
Positive |
Inhibits cellular proliferation. Cell growth suppression via NO may be mediated through Akt signaling |
Sang et al. (2011)
|
Ovarian
|
Negative |
Promotes cellular proliferation. While NO was reduced, there was inhibited cell proliferation in HOC-7 cells |
Keith Bechtel and Bonavida (2001)
|
Breast
|
Negative |
Promotes cellular proliferation. Via inactivation of RAS, there is an NO-induced increase in proliferation |
Pervin et al. (2007)
|
Hepatic
|
Positive |
Promotes apoptosis. In high doses, NO was able to promote apoptosis via p38MAP-kinase |
Wang et al. (2011)
|
|
Negative |
Inhibits apoptosis. In low doses, NO inhibited apoptosis via iNOS/akt/surviving axis |
Wang et al. (2011)
|