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. 2020 Feb 6;14(1):1557988320903191. doi: 10.1177/1557988320903191

Table 1.

Role of Nitric Oxide (NO) in Various Cancer Types.

Cancer type Role of NO Outcome Reference
Prostate Positive In vivo tumor inhibition: This study validates the significance of NO on inhibition of castration-resistant prostate cancer (CRPC) tumors through tumor microenvironment (TME) Arora et al. (2018)
Shows the ability of NO to attenuate hypoxia-induced progression of prostate cancer Siemens et al. (2009)
Small molecules able to inhibit WNT and androgen receptor (AR) signaling via NO release represent a promising platform for the development of new compounds for the treatment of CRPC Laschak et al. (2012)
Inhibits epithelial–mesenchymal transition. Treatment of human prostate metastatic cell lines with the NO donor, DETANONOate, inhibits epithelial–mesenchymal transition and reverses both the mesenchymal phenotype and the cell-invasive properties Baritaki et al. (2010)
Inhibits cellular proliferation. GIT-27NO, an NO donor, inhibited in vivo prostate cancer cell growth of PC3 and LnCap cells Donia et al. (2009)
Lung Positive Decrease in epithelial–mesenchymal transition. NO serves a critical role in preserving an epithelial phenotype and in attenuating epithelial–mesenchymal transition in alveolar epithelial cells Vyas-Read et al. (2007)
Negative Promotes angiogenesis. In vivo, NO has a role in maintaining tumor blood supply, and we provide early clinical evidence that inhibition of NO synthesis has tumor antivascular activity Ng et al. (2007)
Gastric Positive Inhibits cellular proliferation. Cell growth suppression via NO may be mediated through Akt signaling Sang et al. (2011)
Ovarian Negative Promotes cellular proliferation. While NO was reduced, there was inhibited cell proliferation in HOC-7 cells Keith Bechtel and Bonavida (2001)
Breast Negative Promotes cellular proliferation. Via inactivation of RAS, there is an NO-induced increase in proliferation Pervin et al. (2007)
Hepatic Positive Promotes apoptosis. In high doses, NO was able to promote apoptosis via p38MAP-kinase Wang et al. (2011)
Negative Inhibits apoptosis. In low doses, NO inhibited apoptosis via iNOS/akt/surviving axis Wang et al. (2011)