Table 1.

PICOS Question for the Study

Domain	Description
Focus question	Is there any additional benefit of CGF on guided bone regeneration and implant therapy over traditional approaches in terms of clinical, histological, and radiographic outcomes?
Population	Human subjects with lack of alveolar bone and need of implant therapy (immediate placement or conventional)
Intervention	Use of CGF alone or in combination with a graft material in guided bone regeneration techniques and implant therapy
Comparison	Respective surgical procedure without CGF or change in baseline data using CGF
Outcome	Alveolar bone regeneration, soft tissue healing, osseointegration, implant stability, vertical bone gain, and implant survival rate
Study design	Randomized controlled clinical trials, prospective study, and retrospective study

CGF: Concentrated growth factor