Table 5.

Included studies: Bone gain around implant

Study (year)	Type of study	Duration of study	No. of patients (implants)	Site of operation	Groups T: Test group C: Control group	Outcome (mean±SD)
Isler S et al (2018)	RCT	12 months	52 (52)	Not specified	T=CGF	T=1.63±1.00 mm
					C=Collagen membrane (Bio Guide)	C=1.98±0.75 mm P=0.154 (NS)
Kim J et al (2014)	Retrospective study	23.8 weeks	10 (16)	Maxillary posterior	T=CGF	T=8.236±2.88 mm, varying from 4.2-12.7 mm. P<0.05 (S)
					No control group
S Manoj et al (2018)	Prospective study	6 months	10 (10)	Mandibular posterior	T=CGF	T=2.7 mm (mesial), 4.26 mm (distal), 2.3 mm (buccal) and 1.52 mm (lingual), P<0.05 (S)
					No control group
Shetty M et al (2018)	Prospective study	6 months	20	Maxillary posterior	T: CGF	T=1.932±2.22 (mesial),
					C: Without CGF	2.621±1.76 (distal), 3.864±1.51 (palatal), 4.417±2.01 (buccal)
Yang L et al (2014)	Prospective study	12 months	20 (20)	Maxillary posterior	T=CGF C=Bio-oss	T=0.85±0.25mm C=0.35±0.25mm. P<0.05 (S)
Chen Y et al (2016)	Retrospective study	2 years with follow up at 19.88 months	16 (25)	Maxillary posterior	T=CGF	T=9.21±0.66 mm.
					No control group	P<0.05 (S)