Table 1.
The 67 pleiotropic genes identified by the metaCCA and VEGAS2 analysis.
| Locus | Gene | MetaCCA P-value | VEGAS P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CEL | IBD | MS | PBC | RA | SLE | T1D | |||
| 1 | ADAD1a | 1.05E-30 | 1.00E-06 | 1.00E-06 | 0.29 | 1.23E-02 | 1.10E-05 | 2.58E-02 | 6.97E-03 |
| 2 | ADCY5 | 1.44E-06 | 2.40E-02 | 3.91E-02 | 1.00E-06 | 3.75E-02 | 1.29E-02 | 1.32E-02 | 0.87 |
| 3 | AHI1 | 2.03E-87 | 5.05E-02 | 0.30 | 1.00E-06 | 0.36 | 0.54 | 1.94E-03 | 4.75E-02 |
| 4 | ATG5 | 1.53E-16 | 0.33 | 7.00E-06 | 0.53 | 1.87E-03 | 1.54E-03 | 1.00E-06 | 0.94 |
| 5 | C1orf106 | 1.82E-33 | 0.09 | 3.09E-02 | 7.79E-02 | 1.22E-02 | 1.00E-06 | 5.30E-05 | 3.73E-02 |
| 6 | C1orf141a | 7.70E-11 | 0.44 | 1.00E-06 | 0.87 | 1.00E-06 | 9.85E-03 | 2.93E-03 | 0.53 |
| 7 | C5orf56 | 1.87E-16 | 2.07E-03 | 1.00E-06 | 0.29 | 0.67 | 9.41E-02 | 1.86E-02 | 6.48E-02 |
| 8 | CALUa | 2.10E-10 | 0.20 | 1.75E-02 | 2.21E-02 | 1.00E-06 | 1.00E-06 | 1.00E-06 | 7.18E-02 |
| 9 | CCDC136a | 3.51E-25 | 0.030 | 2.90E-02 | 0.38 | 1.00E-06 | 1.00E-05 | 1.00E-06 | 0.39 |
| 10 | CD58 | 5.43E-13 | 0.520 | 2.44E-02 | 0.158 | 0.71 | 1.00E-06 | 0.60 | 6.64E-02 |
| 11 | CIITAa | 4.85E-28 | 4.05E-03 | 0.21 | 1.00E-06 | 1.00E-06 | 0.54 | 1.47E-04 | 1.00E-06 |
| 12 | CLEC16Aa | 9.26E-85 | 1.28E-02 | 2.12E-03 | 1.00E-06 | 1.00E-06 | 0.62 | 1.00E-06 | 1.00E-06 |
| 13 | CUL2 | 2.56E-19 | 0.40 | 1.00E-06 | 0.39 | 2.91E-02 | 0.78 | 4.12E-04 | 5.76E-02 |
| 14 | CUX2 | 2.28E-34 | 0.45 | 7.00E-06 | 0.119 | 2.60E-03 | 3.06E-02 | 0.12 | 1.00E-06 |
| 15 | DEAF1 | 7.99E-14 | 0.40 | 9.22E-02 | 0.85 | 9.31E-02 | 0.86 | 1.00E-06 | 0.42 |
| 16 | DGKQ | 1.61E-15 | 0.88 | 0.43 | 2.18E-03 | 1.00E-06 | 9.95E-02 | 4.57E-03 | 0.32 |
| 17 | DNMT1 | 6.97E-07 | 0.39 | 6.87E-04 | 7.82E-04 | 2.00E-06 | 5.03E-04 | 1.00E-06 | 9.33E-02 |
| 18 | EFR3Ba | 1.70E-99 | 0.34 | 1.00E-06 | 2.72E-02 | 1.00E-06 | 2.78E-03 | 0.47 | 1.54E-02 |
| 19 | ERAP2 | 1.77E-49 | 0.98 | 1.00E-06 | 0.25 | 6.88E-04 | 0.45 | 0.57 | 4.76E-02 |
| 20 | EVI5 | 4.08E-19 | 0.39 | 0.23 | 1.00E-06 | 0.65 | 1.18E-02 | 0.23 | 1.50E-02 |
| 21 | FGF2a | 1.78E-08 | 1.00E-06 | 1.00E-06 | 9.08E-03 | 0.39 | 3.04E-03 | 0.18 | 1.40E-05 |
| 22 | FYCO1 | 2.73E-11 | 1.00E-06 | 2.45E-02 | 1.00E-02 | 0.74 | 0.49 | 0.57 | 0.86 |
| 23 | GRIP1 | 2.20E-62 | 1.39E-02 | 1.00E-06 | 0.20 | 0.25 | 0.25 | 4.43E-02 | 0.73 |
| 24 | HNF1B | 2.17E-10 | 0.14 | 5.60E-03 | 0.44 | 0.11 | 2.94E-02 | 0.31 | 1.00E-06 |
| 25 | IKZF1 | 4.37E-10 | 0.02 | 0.42 | 7.70E-02 | 0.29 | 4.02E-04 | 0.49 | 1.00E-06 |
| 26 | IKZF3 | 2.57E-203 | 0.41 | 1.00E-06 | 9.31E-02 | 0.47 | 0.43 | 0.54 | 2.63E-02 |
| 27 | IL22RA2 | 1.55E-11 | 0.19 | 0.46 | 1.00E-06 | 2.85E-03 | 0.67 | 3.28E-02 | 0.12 |
| 28 | IL23Ra | 1.00E-232 | 0.90 | 1.00E-06 | 0.45 | 1.00E-06 | 0.11 | 8.16E-02 | 0.91 |
| 29 | INPP1 | 3.40E-06 | 0.35 | 0.25 | 0.695 | 4.30E-05 | 3.65E-03 | 1.00E-06 | 0.56 |
| 30 | IRF1 | 6.56E-72 | 9.87E-03 | 1.00E-06 | 4.58E-02 | 0.42 | 3.38E-02 | 0.53 | 5.98E-02 |
| 31 | ITGAM | 2.41E-48 | 5.22E-02 | 0.80 | 7.03E-02 | 0.17 | 0.20 | 1.00E-06 | 0.23 |
| 32 | JAK2 | 6.34E-118 | 0.18 | 1.00E-06 | 2.21E-03 | 0.63 | 0.40 | 8.33E-02 | 0.53 |
| 33 | KIAA1109 | 5.27E-16 | 2.00E-06 | 1.00E-05 | 1.79E-03 | 0.12 | 4.27E-02 | 0.35 | 1.00E-06 |
| 34 | LINC00271 | 1.22E-08 | 1.63E-02 | 0.97 | 1.00E-06 | 0.48 | 0.26 | 1.16E-03 | 1.78E-03 |
| 35 | LOC101927051a | 5.60E-11 | 0.55 | 1.00E-06 | 0.13 | 1.00E-06 | 3.00E-06 | 4.24E-04 | 4.84E-03 |
| 36 | LOC285626 | 3.83E-97 | 0.50 | 1.00E-06 | 5.05E-02 | 0.40 | 0.74 | 0.94 | 0.51 |
| 37 | LTF | 5.48E-09 | 1.00E-06 | 0.17 | 0.33 | 0.76 | 5.55E-02 | 0.93 | 1.51E-04 |
| 38 | MACROD2 | 9.46E-07 | 0.35 | 4.60E-05 | 2.91E-02 | 1.00E-06 | 6.85E-03 | 0.12 | 1.88E-02 |
| 39 | MAGI3a | 7.55E-24 | 0.65 | 1.10E-02 | 0.27 | 0.81 | 1.00E-06 | 8.90E-05 | 1.00E-06 |
| 40 | MAP3K7 | 2.77E-66 | 0.30 | 1.00E-06 | 0.31 | 7.85E-02 | 0.25 | 0.48 | 0.46 |
| 41 | MAP4K4a | 3.30E-24 | 1.00E-06 | 1.00E-06 | 0.15 | 5.08E-02 | 0.73 | 9.30E-03 | 7.47E-02 |
| 42 | MPZL3a | 5.37E-09 | 1.45E-02 | 0.86 | 6.22E-04 | 1.00E-06 | 1.00E-06 | 1.45E-03 | 0.18 |
| 43 | MST1R | 3.72E-37 | 0.93 | 1.00E-06 | 0.56 | 0.4588 | 0.84 | 1.27E-02 | 5.08E-02 |
| 44 | NSD1 | 1.16E-25 | 0.55 | 1.00E-06 | 1.00E-05 | 0.16 | 1.42E-02 | 0.55 | 1.44E-02 |
| 45 | PAPOLGa | 7.00E-08 | 4.00E-06 | 1.00E-06 | 1.07E-02 | 0.11 | 1.00E-06 | 4.40E-02 | 0.50 |
| 46 | PLCL2 | 2.97E-17 | 0.18 | 0.22 | 1.50E-02 | 3.00E-06 | 1.00E-06 | 0.62 | 0.72 |
| 47 | PRKAA1 | 4.54E-18 | 0.12 | 1.00E-06 | 3.90E-02 | 0.371 | 0.34 | 0.12 | 0.30 |
| 48 | PTPN2a | 1.06E-09 | 6.00E-06 | 1.00E-06 | 7.66E-03 | 9.56E-02 | 1.00E-06 | 0.15 | 1.00E-06 |
| 49 | PUS10 | 5.93E-101 | 7.00E-06 | 1.00E-06 | 1.60E-02 | 0.40 | 0.20 | 0.16 | 7.89E-02 |
| 50 | RBM17a | 2.49E-25 | 0.252 | 3.36E-02 | 3.10E-05 | 0.64 | 1.00E-06 | 0.47 | 1.00E-06 |
| 51 | RNASET2 | 1.22E-08 | 0.162 | 1.00E-06 | 0.99 | 4.08E-04 | 1.77E-02 | 8.93E-02 | 0.24 |
| 52 | SH3BP1a | 5.60E-11 | 0.562 | 1.00E-06 | 0.11 | 1.00E-06 | 3.00E-06 | 4.39E-04 | 4.35E-03 |
| 53 | SHISA5 | 5.12E-118 | 3.68E-02 | 1.00E-06 | 0.32 | 0.70 | 0.60 | 0.46 | 0.14 |
| 54 | SLC26A4 | 1.29E-35 | 0.90 | 1.00E-06 | 2.79E-02 | 0.17 | 0.90 | 0.23 | 9.07E-02 |
| 55 | THADA | 9.70E-149 | 0.48 | 1.00E-06 | 0.30 | 0.51 | 0.83 | 4.70E-02 | 2.17E-03 |
| 56 | TNFAIP3 | 6.86E-33 | 0.48 | 0.38 | 1.99E-04 | 2.60E-03 | 9.00E-06 | 1.00E-06 | 5.88E-02 |
| 57 | TNIK | 3.66E-54 | 1.00E-06 | 0.198 | 5.73E-04 | 8.17E-02 | 0.34 | 2.71E-03 | 8.36E-02 |
| 58 | TNIP1 | 3.52E-34 | 0.12 | 0.158 | 0.49 | 4.82E-04 | 9.01E-04 | 1.00E-06 | 0.39 |
| 59 | TNS1 | 1.56E-18 | 0.11 | 1.00E-06 | 0.64 | 3.03E-02 | 8.87E-02 | 0.88 | 2.76E-02 |
| 60 | TP63 | 1.05E-26 | 1.00E-06 | 2.00E-06 | 2.85E-02 | 0.33 | 0.68 | 0.25 | 7.99E-02 |
| 61 | TRPV4 | 2.37E-09 | 3.43E-04 | 3.74E-02 | 0.15 | 1.46E-03 | 1.13E-03 | 0.25 | 1.00E-06 |
| 62 | TTC34 | 1.98E-09 | 5.60E-05 | 1.19E-02 | 1.00E-06 | 4.60E-05 | 1.30E-04 | 4.65E-02 | 0.46 |
| 63 | TYK2 | 1.06E-06 | 0.11 | 1.00E-06 | 3.00E-06 | 2.80E-05 | 5.00E-06 | 7.00E-06 | 3.82E-03 |
| 64 | USP34 | 9.72E-217 | 4.00E-06 | 1.00E-06 | 4.59E-02 | 0.38 | 1.15E-02 | 0.40 | 0.35 |
| 65 | WDR78 | 4.90E-52 | 2.04E-03 | 1.00E-06 | 0.12 | 8.53E-03 | 1.30E-02 | 0.85 | 0.76 |
| 66 | WNT11 | 4.60E-19 | 0.19 | 1.00E-06 | 0.83 | 0.19 | 0.33 | 0.47 | 0.45 |
| 67 | ZNF365 | 1.41E-164 | 0.25 | 1.00E-06 | 0.16 | 0.55 | 0.12 | 4.37E-02 | 0.36 |
a
This gene was associated with more than one disease in the VEGAS2 analysis.