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A) Schematic of the TULIP system in the dark state. Stargazin-GFP-LOVpep sits in the closed confirmation at the plasma membrane next to inactive RhoA. The 2x-PDZ-mCherry-LARG sits diffusely in the cytoplasm. B) Schematic of the TULIP system in the activated state. 405nm light causes a conformational change of the Stargazin-GFP-LOVpep that increases the binding affinity to the 2X-PDZmCherry LARG, recruiting it to the membrane where it activates RhoA.
