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. 2020 Feb 3;10:46. doi: 10.3389/fonc.2020.00046

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Copyright © 2020 Wang, Lu, Dai, Fu, Hao, Zhao, Chen and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cav-1-dependent increase of Met leads to the cisplatin-resistance of gastric cancer cells. (A) The cell survival rate of AGS/CDDP cells was elevated compared with AGS cells. AGS/CDDP cells showed stronger anti-cisplatin capability than their parental cells. (B) AGS/CDDP cells showed a higher level of Cav-1 mRNA compared with control cells. (C) Met mRNA expression was markedly increased in AGS/CDDP cells. (D) The protein levels of Cav-1 and Met were in consistent with the mRNA expression in AGS cells. (E) The relative levels of Met and Cav-1 in AGS and AGS/CDDP cells were analyzed. Data are shown as mean ± SEM (n = 3). *P < 0.05, **P < 0.01, ***P <0.001 compared with AGS cells. CDDP, cisplatin.