Table 6.
Duration of surveillance periods of cynomolgus macaques exposed to different prion isolates
| Route and quantity of inoculum | BSE | vCJD | Scrapie(Comoy et al., 2015) | MD CWD(Race et al., 2018) | Elk CWD(Race et al., 2018) | WTD CWD(Race et al., 2018) |
|---|---|---|---|---|---|---|
| IC route, 40/50 mg | 31–49 mpi (6/6)(Montag et al., 2013) | 25–44 mpi (5/5) (Herzog et al., 2005) | 118 mpi (1/1) | – | – | – |
| IC route, 5 mg | – | – | – | 48–160 mpi (0/2) | 95–161 mpi (0/2) | 79–88 mpi (0/2) |
| IC route, 0.5 mg | 47–93 mpi (3/4)(Comoy et al., 2015) | – | – | – | – | – |
| Clinical outcome | 9/10 BSE | 5/5 vCJD | 1/1 Scrapie | AggressionEnd of study | SeizuresEnd of study | DiabetesWasting |
| Oral route, 4/5 g | 52–63 mpi (6/7)(Lasmezas et al., 2005; Holznagel et al., 2013) | – | – | 97‐106‐142 mpi (0/3) | 131‐149‐157 mpi (0/3) | 106–160 mpi (0/2) |
| Clinical outcome | 6/7 BSE | – | – | TremorDiabetesAnorexia | DiabetesHaemorrhoidsAbdominal pain | DiabetesEnd of study |
IC: intracerebral; CWD: chronic wasting disease; MD: mule deer; WTD: white‐tailed deer.
mpi: months post‐inoculation. (X/Y): attack rate; number of positive animals out of the number of exposed animals.