Table 1.

Maternal Characteristics of Polypeptide – Treated Rats in the Placental Ischemia Model.

Metrics	Sham Saline	RUPP Saline	Sham SynB1 -ELP (50 mg/kg/ d)	RUPP SynB1 -ELP (50 mg/kg /d)	Sham Free p50i (2 mg/k g/d)	RUPP Free p50i (2 mg/kg/ d)	Sham SynB1 -ELP- p50i (50 mg/kg /d)	RUPP SynB1 -ELP- p50i (50 mg/kg /d)	Sham SynB1 -ELP- p50i (75 mg/kg /d)	RUPP SynB1 -ELP- p50i (75 mg/kg /d)
Maternal Body Weight (g)	291 ± 23	262 ± 15*	281 ± 13	263 ± 12	297 ± 16	264 ± 25*	301 ± 10	271 ± 19*	293 ± 21	266 ± 22*
Maternal MAP (mmHg)	100 ± 13	120 ± 11*	99 ± 10	123 ± 6*	103 ± 10	115 ± 9	98 ± 9	111 ± 5	92 ± 12	112 ± 10*
Maternal Heart Weight (g)	0.77 ± 0.10	0.82 ± 0.10	0.71 ± 0.04	0.72 ± 0.08	0.79 ± 0.04	0.76 ± 0.05	0.75 ± 0.08	0.80 ± 0.08	0.77 ± 0.12	0.86 ± 0.11
Maternal Kidney Weight (g)	0.81 ± 0.09	0.85 ± 0.09	0.76 ± 0.08	0.84 ± 0.08	0.81 ± 0.07	0.81 ± 0.10	0.77 ± 0.09	0.82 ± 0.1	0.80 ± 0.08	0.87 ± 0.1*
Total Litter Size (GD14, pre-surgery)	11.3 ± 1.8	11.8 ± 1.5	10.7 ± 0.9	11.1 ± 1.5	11.3 ± 1.0	11.7 ± 1.2	11.4 ± 1.6	12.0 ± 1.5	10.7 ± 1.5	12.1 ± 1.8
Reabsorption Rate (%)	5.9 ± 10.1	69.5 ± 14.2*	17.5 ± 18.8	76.7 ± 16.2*	9.7 ± 10.2	66.6 ± 11.7*	4.8 ± 7.3	70.8 ± 18.9*	12.6 ± 20.1	68.3 ± 18.4*
Placental Weight (g)	0.62 ± 0.05	0.59 ± 0.07	0.59 ± 0.09	0.53 ± 0.09	0.63 ± 0.04	0.53 ± 0.07	0.55 ± 0.06	0.55 ± 0.12	0.62 ± 0.06	0.60 ± 0.10
Fetal Weight (g)	2.56 ± 0.20	2.43 ± 0.20	2.51 ± 0.29	2.24 ± 0.28	2.57 ± 0.32	2.22 ± 0.28	2.47 ± 0.15	2.33 ± 0.20	2.55 ± 0.19	2.46 ± 0.25
Placental Efficiency	4.15 ± 0.40	4.16 ± 0.59	4.27 ± 0.51	4.32 ± 0.76	4.10 ± 0.32	4.20 ± 0.55	4.54 ± 0.45	4.35 ± 0.78	4.14 ± 0.26	4.17 ± 0.61

Mean ± SD are shown.

^*Statically significant difference between Sham and RUPP operated rats with the same test agent treatment were assessed using a two-way ANOVA with post-hoc Tukey’s multiple comparison of all groups pair-wise.