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Roles of NBD dimerization and ATP hydrolysis in N1303K-CFTR gating. Representative single channel recordings of G551D/N1303K (A), G1349D/N1303K (B) and E1371S/N1303K at 2 mM ATP. Microscopic kinetic analysis revealed mean open times (τO) for G551D/N1303K, G1349D/N1303K and E1371S/N1303K are 3.0 ± 0.5 s (n = 3), 3.0 ± 1.1 s (n = 3) and 3.0 ± 0.3 s (n = 6), respectively. Note: τO = 3.1 ± 0.8 s for N1303K-CFTR (Fig. 2).
