Table 3.

Multivariable Diet Adjusted Percent Change in Metabolite Concentrations for Categories of Alcohol Consumption^a

	Drinks per Week
	0	>0 and <1	≥1 and <5	≥5 and <10	≥10 and ≤40
N	17	41	81	46	26
Sarcosine
% change	−5.44	ref	−1.90	21.49	138.02
95% CIb	−39.36, 47.43		−27.23, 32.24	−14.97, 73.57	55.52, 264.29
Pvalue	0.815		0.905	0.312	<0.001
Eicosapentaenoate
% change	−1.56	ref	10.46	23.52	59.87
95% CI	−26.80, 32.39		−9.50, 34.80	−2.64, 56.71	20.36, 112.36
Pvalue	0.921		0.355	0.101	0.002
4-Androsten-3beta,17beta-diol monosulfate
% change	−8.43	ref	6.01	50.68	97.88
95% CI	−38.58, 36.53		−18.96, 38.66	9.32, 107.67	34.96, 190.15
Pvalue	0.682		0.687	0.019	0.001
4-Androsten-3beta,17beta-diol disulfate
% change	10.58	ref	3.13	53.52	123.64
95% CI	−26.31, 65.92		−21.50, 35.48	10.82, 112.68	51.60, 229.93
Pvalue	0.646		0.834	0.015	<0.001
Gamma-CEHC
% change	−13.26	ref	−27.84	−33.63	−41.50
95% CI	−34.91, 14.89		−40.75, −13.19	−47.44, −17.04	−55.72, −23.68
Pvalue	0.355		0.002	0.001	<0.001
2-Methylcitrate
% change	−4.85	ref	−7.58	−3.25	19.51
95% CI	−17.84, 9.56		−16.03, 1.90	−13.96, 8.41	4.09, 37.14
Pvalue	0.522		0.133	0.595	0.017

^aResults from linear mixed effects regression of individual metabolite concentrations on alcohol intake modeled as a factor with 5 levels and adjusted as described in Table 2 footnote c.

^bCI=confidence interval